This is a list of notable events, premieres, releases, series cancellations and endings, and other business ventures for Nickelodeon in the year 1992.
- January 4 - Nick Arcade
- August 15 - Roundhouse premieres as part of SNICK, accompanied by the official series premiere of Are You Afraid of the Dark?
- August 23 - Nickelodeon Wild Side Show
- September 19 - Nickelodeon GUTS
- February 14 - Clarissa Explains It All season 2
- August 15 - The Ren & Stimpy Show season 2
- September 6 - Rugrats season 2
- September 13 - Doug season 2
- August 15 - SNICK (Saturday Night Nickelodeon)
- October - Marvel Comics begins publishing a monthly comic book series based on The Ren & Stimpy Show
Behind the scenes
- September 29 - John Kricfalusi and the original production team behind The Ren & Stimpy are fired due to creative differences; Games Animation is set up by Nick to continue production on the show. Billy West assumes the role of Ren Höek.
- April 30 - A time capsule is buried at Nickelodeon Studios. The burial is televised, and is hosted by Mike O'Malley.
- Gak is introduced.
- February 9- Avan Jogia is born
- April 4- Alexa Nikolas is born
- June 14 - Daryl Sabara is born
- June 21- Max Schneider is born
- June 26 - Jennette McCurdy is born
- July 3 - Nathalia Ramos is born
- August 9 - Burkely Duffield is born
- August 21 - Brad Kavanagh is born
- October 9 - Tyler James Williams is born
- November 18 - Nathan Kress is born
- November 25 - Zack Shada is born
Nickelodeon character debuts
- Rugrats wins its first Emmy Award.