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This is a list of notable events, premieres, releases, series cancellations and endings and other business ventures for Nickelodeon in the year 2010.
- January 25 - Team Umizoomi
- March 27 - Victorious
- April 24 - 7 Secrets
- October 2 - Planet Sheen and T.U.F.F. Puppy.
- ? - Shimmer and Shine (Pilot Episode)
- May 31 - The Backyardigans
Australian TV show
- July 1 - The Last Airbender
- March 9 - SpongeBob to the Rescue!
- April 6 - SpongeBob, Soccer Star!
- June 1 - Avatar: The Last Airbender - The Art of the Animated Series
- August 24 - Crash Course!
- September 21
- October 5 - Christmas with Krabby Klaws
Home video releases
- January 26 - SpongeBob SquarePants: Viking-Sized Adventures
- February 9 - The Penguins of Madagascar: Operation: DVD Premiere
- March 16 - SpongeBob SquarePants: SpongeBob's Last Stand
- March 30 - iCarly: iFight Shelby Marx
- June 8 - iCarly: iSaved Your Life
- July 13 - SpongeBob SquarePants: Triton's Revenge
- August 10
- The Penguins of Madagascar: Happy King Julien Day!
- The Penguins of Madagascar: New to the Zoo
- August 31 - iCarly: iSpace Out
- November 16
- The Last Airbender
- SpongeBob SquarePants: Legends of Bikini Bottom
- May 4
- Invader Zim: Season 1
- Invader Zim: Season 2
- August 10 - Aaahh!!! Real Monsters: Season 1
- December 1
- Aaahh!!! Real Monsters: Season 2
- Aaahh!!! Real Monsters: Season 3
- Aaahh!!! Real Monsters: Season 4
- The Wild Thornberrys: Season 2, Volume 1
- The Wild Thornberrys: Season 2, Volume 2
- The Wild Thornberrys: Season 3, Volume 1
- The Wild Thornberrys: Season 3, Volume 2
- The Wild Thornberrys: Season 3, Volume 3
- The Wild Thornberrys: Season 4
- The Wild Thornberrys: Season 5
- December 8
- The Angry Beavers: The Best of Season 2
- The Angry Beavers: The Best of Season 3
- February 1
- February 22
- Rugrats: A Bland New Chuckie
- Rugrats: I Am the Great Angelica
- Rugrats: Phil and Lil - Twice as Nice
- Rugrats: Tommy Pickles - Natural Bald Leader!
- March 8 - Salute Your Shorts: Volume One
- March 15
- March 22 - Victorious: Season One
- March 29
- April 5 - Yo Gabba Gabba: Season Three
- May 10 - The Fairly OddParents: Season Seven
- June 21 - The Best of Clarissa Explains It All, Volume Two
- July 26 - Hey Dude: Season Two
- July 31 - iCarly: Volume Four
- August 9 - Salute Your Shorts: Volume Two
- August 23 - The Best of Rugrats, Volume Three
- August 30 - The Fresh Beat Band: Season Two
- September 11 - True Jackson, VP: Season Three
- September 24 - Big Time Rush: Season One and Two
- November 15 - Rugrats: Holiday Collection