This is a list of notable events, premieres, releases, series cancellations, endings, and other business ventures for Nickelodeon in the year 2016.
- January 18 - The HALO Effect
- January 30 - Power Rangers Dino Super Charge
- February 1 - Paradise Run
- March 12 - School of Rock
- April 10 - The Other Kingdom
- May 2 - The Loud House
- June 3 - All in With Cam Newton
- June 13 - Pinky Malinky
- July 5 - Crashletes
- July 9 - Legendary Dudas
- July 25 - Welcome to the Wayne
- August 13 - Regal Academy
- September 9 - Jagger Eaton's Mega Life
- October 3 - Kuu Kuu Harajuku
- October 24 - Rank the Prank
- November 8 - Rusty Rivets
- January 15 - The Fairly OddParents, season 10.
- June 13 - Harvey Beaks, season 2.
- June 15 - Shimmer and Shine, season 2.
- June 21 - Rabbids Invasion, season 3 on Nicktoons.
- September 16 - Crashletes, season 2.
- November 9 - The Loud House season 2
- October 15 - SpongeBob SquarePants, season 10.
- October 22 - The Thundermans, season 4.
- November 9 - The Loud House, season 2.
- November 20 - Pig Goat Banana Cricket, season 2 on Nicktoons.
- February 27 - 100 Things to Do Before High School
- June 25 - Bella and the Bulldogs
- June 29 - Kung Fu Panda: Legends of Awesomeness, three seasons
- July 29 - Sanjay and Craig, three seasons
- September 12 - Breadwinners, two seasons
- October 23 - As Told by Ginger, three seasons. Aired its last episode for the US on The Splat
- June 18 - Danger & Thunder
- September 16 - Booby Trapped
- November 23 - The Double Dare Reunion Special
- December 9 - Albert
Australian TV series
- September 26 - Hi-5 House premiered its third season on Nick Jr.
- Play Along with Sam premiered on Nick Jr.
- January 26 - Harvey Beaks #1: Inside Joke
Home video releases
- January 26 - Nickelodeon Favorites: Whiskers & Paws
- March 15 - Teenage Mutant Ninja Turtles: Half-Shell Heroes: Blast to the Past
- April 19 - Dive In and Roll Out
- May 24 - Teenage Mutant Ninja Turtles: Beyond the Known Universe
- June 7 - The SpongeBob Movie Collection (box set)
- July 12 - Blaze and the Monster Machines: Fired Up!
- August 2 - Paw Patrol: Sports Day
- October 11 - A Very Nick Jr. Christmas
- November 1 - Paw Patrol: Pups Save Christmas
- December 13
- The Legend of Korra: The Complete Series
- Teenage Mutant Ninja Turtles: Earth's Last Stand
- September 9 - NickMusic begins broadcasting with Pharrell Williams' Happy, replacing MTV Hits
Nickelodeon character debuts
- The Fairly OddParents: Chloe Carmichael
- The Loud House: Lynn Loud Sr., Rita Loud, Howard and Harold McBride, Bobby Santiago, Ronnie Anne Santiago, Agnes Johnson, Mr. Grouse, Flip, Mick Swagger, Albert
- January 6 - Pat Harrington Jr. dies
- January 10 - David Bowie dies
- January 26 - Abe Vigoda dies
- February 3 - Joe Alaskey dies
- May 19 - Alan Young dies
- June 7 - Russell Hicks steps down from his position of President, Content Development and Production
- August 19 - Jack Riley dies
- November 26 - Ron Glass dies
- December 28 - Debbie Reynolds dies