Kids
- Amanda Bynes
- Alisa Reyes
- Angelique Bates
- Christy Knowings
- Danny Tamberelli
- Gabriel Iglesias
- Josh Server
- Katrina Johnson
- Kel Mitchell
- Kenan Thompson
- Leon Frierson
- Lori Beth Denberg
- Mark Saul
- Nick Cannon
First Run- "The Golden Era"
- Allen (professional cereal critic, reviews cereal like "Lucky Germs" and "Friut Poots" with his partner Alan) (Seasons 1-2)
- Detective Dan (a clumsy, incompetent, delusional police detective) (Seasons 2-6)
- Dr. Bynes (very disgusting dentist)(Seasons 3-4)
- Fizz (drive-through guy at Good Burger. Called Marty in the first appearance in the sketch) (Seasons 1-2)
- Flem (savage, disgusting teen. Spoof of Goofus of Goofus and Gallant) (Seasons 2-4)
- Jimmy Bond (teenage secret agent one-seventh, spoof of James Bond) (Seasons 1, 4-6)
- Julio (cafeteria worker at Dullmont Junior High under peas-loving Miss Pidlin) (Seasons 3-5)
- Milkman (a rogue milkman; nemesis of Superdude)(Seasons 1-3)
- Tandy Spork (highly medicated vegetarian secretary of Dullmont High School) (Seasons 3-5)
- Walter the Earboy (a high school student with freakishly large ears) (Seasons 1-3, 5)
- Ray Borealis (reporter of Channel 6 1/2 News, often in perilous and disgustin places)(Season 5-6)
- Studs Wilkinson (sidekick of Francis the Caveman, spoof of Ed MaHoon) (Season 6)
- Toby Braun (former fitness expert, makes informercials for seemingly useless items, spoof of Tony Little) (Season 4 & 6)
- Mumble Spice (Spice Boy with poor acculation)(Season 5-6)
- Bernie Kibbitz (old yiddish man, claims tobe 130 years old. Frequent customer of Good Burger.)(Season 3-6)
- Emily Maroon (Lump Maroon's brother that always laughs) (Season 3)
- Officer Canker (serves on the USS Spaceship under Captain Tantrum) (Season 3-4)
- Dusty Pants (cowboy student in Ms. Fingerly's Class) (Season 3-4)
- Mr. McToad (hideous half-man/half-toad seeking help from Wizard of Cos) (Season 2)
- Mack Tackahashi (co-anchor of Channel 6 1/2 Sports, not related to Jack Tackahashi)(Season 5)
- 'Squash Hick' (hayseed who enjoys fishing, buses, & his friend Squash Boy)(Season 3-4)
- Jerry Footall (later Jerry Futile)(host of game shows "You Can't Win" & "Cockroaches in your pants") (Season 3-6)
- Dairy Godfather (the godfather of all dairy, enemy of Superdude) (Season 5)
- Voice of Don't Do This at Home or School Scketches (Voice who tells the Audience What not to at home and school) (Season 5)
- Superdude (lactose-intolerant superhero, spoof of Superman) (Seasons 1-5)
- Pierre Escargot (man wearing raincoat in a bathtub, teaches absurd French phrases) (Season 1-5)
- Lester Oaks, Construction Worker (a construction worker who always says his job as part of his name. Frequent customer of Good Burger) (Season 1-5)
- Burt Spice/Spice Cube (Spice Boy who was kicked out for being nerdy, so came back as a rapper, spoof of rapper/actor Ice Cube and the Spice Girls) (Season 5)
- Randy (chocolate-loving TV chef) (Season 1-4)
- Mavis (elderly best friend of Clavis) (Season 1-5)
- Principal William Baines Pimpell (Dullmont Junior High principal with throbbing blemish on his forehead and a lisp) (Season 2-5)
- Miss Piddlin (occasionally violent lunch lady who loves peas) (Season 3-5)
- Fred Mertz (African-American version of original I Love Lucy character) (Season 4)
- Ishboo (possibly fraudulent foreign-exchange student who relies on pity to get his way and has incredibly weird foreign customs) (Season 1-3)
- Bradley the Big-Ol' Baby (an enormous bratty infant) (Season 3)
- LaNeesha (self-centered ghetto female convenience store employee, best friend of LaTanya) (Season 5)* Antoine (short-tempered 60's-70's guy with an afro and a Cloudy Knights member who appears in other sketches as well) (Season 3-5)
- Nasty Nancy (nasty cowboy because of his name, enemy of Dusty Pants) (Season 3-4)
- Baggin' Saggin' Barry (teenager with enormous pants which contain a wide variety of strange items) (Season 1-2)
- Bill Cosby (a spoof of the comedian, also known as the "Wizard of Cos") (Season 1-2)
- Officer Ulcer (serves on the USS Spaceship under Captain Tantrum, spoof of Mr. Scott) (Season 3-4)
- Coldfinger (nemesis of Jimmy Bond, has ice-covered right index, spoof of Goldfinger) (Seasons 1 & 4)
- Seymour (mute boy who reacts to various things) (Season 5)
- "Squash Boy" (character which never appeared due to costume problems, sometimes played by Kel) (Season 3)
- Jack Takahashi ( co-anchor of Channel 6 1/2 Sports, not related to Mack Takahashi) (Season 5)
Kel Mitchell (seasons 1-5)
- Ed (clueless Good Burger counter clerk, known for multiple catchphrases) (Season 1-5)
- Okrah (talk show host, spoof of Oprah) (Season 2-3)
- Pizzaface (Earboy's sensitive best friend, has a slice of pepperoni pizza for a face) (Season 1-3)
- Lump Maroon (A maroon who says nothing but "Jupiter!" and pops up in random sketches) (Season 3-5)
- Clavis (elderly best friend of Mavis) (Season 1-5)
- Peter (well-mannered teen, spoof of Gallant from Goofus & Gallant) (Season 2-4)
- Coach Kreeton (crabby Dullmont Junior High athletic coach who suffers many unfortunate accidents. he lists synonyms for words("hall pass,ticket,slip" for example) (Season 1-5)
- Disco (member of Cloudy Knights, easily manipulated by girlfriend Yoko) (Season 4)
- Repairman-man (insane "hero" who "repairs" things with a sledgehammer and echos his own name) (Season 2-5)
- Officer Colby (member of the Cheese Police) (Season 1-2, Season 4)
- Singo (navigator/gunner of USS Spaceship, sings everything he says) (Season 3-4)
- Alan (professional cereal critic, reviews weird cereal with Allen) (Season 1-2)
- Dr. K (radio advice show host) (Season 1-2)
- Yo-Gurl (woman made of yogurt, enemy of Superdude) (season 3)
- Cow-Boy (half-man, half-cow, enemy of Superdude) (season 4)
- Butter Boy (man made of butter, enemy of Superdude) (season 2)
- Steve Urkel (spoof of the Family Matters character) (Season 1)
- Pasta Mon (Rastafarian man made of noodles who has no sauce, seeks help from the Wizard of Cos) (Season 2)
- "Squash Boy" (character which never appeared due to costume problems, sometimes played by Kenan) (Season 3)
Lori Beth Denberg (seasons 1-4)
- Vital Information gal (girl who imparts pearls of "wisdom" to audience) (Season 1-4, role was then taken up by Tamberelli, then later Lil' JJ)
- Fran (cynical, short-tempered girl stranded on an island with Kiki) (Season 2-3)
- Miss Fingerly (barely-competent Dullmont Junior High teacher) (Season 1-4)
- Ms. Hushbum (a hypocritically loud librarian, hates when others make sound) (Season 2-4)
- Complaint Department lady (IQ-impaired customer service employee) (Season 2-4)
- Ethel Mertz (spoof of the I Love Lucy character) (Season 4)
- Connie Muldoon (eccentric frequent customer of Good Burger, despite constant trouble with Ed) (Season 1-4)
- Manager (owner of "We Got Pants", a store that carries only one pair of slacks) (Season 4)
- Thumbtax (hostile queen of the Thumbtax race, has ridiculous lisp, enemy of the USS Spaceship crew) (Season 3-4)
- Sweaty Woman (Woman who costantly sweats. Appears in Superdude sketchs) (Season 3-4)
- Jenny Plus (Mean Girl Who Steals Earboys Election Idea In Earboys School) (Season 1)
- Mrs. Maroon (Lump Maroon's Mother,Usually When Someone Calls or Knocks She Answers To Random Objects) (Season 3)
Katrina Johnson (seasons 1-3)

- Ross Perot (crazy billionaire and mentor to Earboy, spoof of the politician) (Season 1-3)
- Roseanne Barr (spoof of the raunchy comedian) (Season 1-2)
- Lactose Intolerance-Definer (appears in Superdude skits to define "lactose-intolerant" to nearby civilians, role later reprised by Bynes) (Season 1-3)
- Lemonade Scammer (young girl selling lemonade from a curbside stand and scamming people out of their money sometimes using pity, guilt, or just plain crying) (Season 1-3)
- Dorothy (Main Character In The Wizard Of Cos,Spoof Of Dorthy From The Wizard Of Oz ) (Season 2)
- Bouncer Girl (A Bouncer Who Wont Let Any One Get Past Her) (Season 1)
- Didi (Kiki's younger sister, only appeared once) (Season 3)
Alisa Reyes (seasons 1-3)

- Kiki (upbeat, perky girl stranded on an island with Fran) (Season 2-3)
- Penny Lane (reprising Bates' role as Superdude's Damsel-in-distress) (Season 3)
- Tinsel Teeth (Earboy's friend, has Christmas decor for teeth) (Season 1)
- Sally (Popular Girl in Earboy's school who he has a crush on but thinks he's a freak b/c of his large ears) (Season 1)
- Susumi (communications officer of USS Spaceship under Captain Tantrum, spoof of Lt.Uhura on Star Trek) (Season 3)
- Baggin' Saggin' Mary (Competition To Bagging Sagging Barry) (Season 2)
- Chuck Maroon (Sister To Lump Maroon) (Season 3)
Angelique Bates (season 1-2)

- Mandy (chocolate-loving TV chef, former co-host to Randy) (Season 1-2)
- Steve Urkel (spoof of the Family Matters character) (Season 1-2)
- Four Eyes (Earboy's girlfriend, has four eyes) (Season 1-2)
- Penny Lane (Superdude's damsel in distress spoof of Lois Lane) (Season 1-2)
- Beth (Good Burger Trainee who Ed is in love with. Appears in 4 Good Burger sketches)
Amanda Bynes (seasons 3-6)
- Ashley (short-fused advice-giver who receives many seemingly obvious questions) (Season 3-6)
- Gina (teenybopper valley girl co-host of "What-everrrrr!") (Season 4-6)
- Jiffy Springs (pop singer, spoof of Britney Spears) (Season 6)
- Captain Tantrum (adolescent commander of USS Spaceship) (Season 3-4)
- Skye (spacey artisan) (Season 5)
- Megan Marples (geeky girl with many hidden talents) (Season 4-5)
- Lucy Ricardo (spoof of the I Love Lucy protagonist) (Season 4)
- Lactose Intolerance-Definer (reprising Katrina Johnson's role after Johnson left the show) (Season 4-5)
- Classical music girl (plays multiple classical instruments in extremely inappropriate situations or ways) (Season 3-4)
- Dr. Debbie (cheerleading physician) (Season 6)
- 'Squash'-Girl (companion to 'Squash'-hick) (Season 3)
- Evil Superdude (impostor who people could not tell apart from the real superhero) (Season 3)
- Penelope Taynt (recurring character from The Amanda Show, used in a season 7 episode)
Tricia Dickson (season 3)
- none
Danny Tamberelli (seasons 4-6)
- Vital Information guy (took over role after Denberg left the show) (Season 5-6)
- Hairy Spice (Spice Boy with thick body hair and English accent) (Season 5-6)
- Boring Man (the dullest superhero ever with the power to bore people to sleep) (Season 6)
- Janitor Gasious (cranky, disgusting Dullmont Junior High janitor, burps constantly) (Season 4-5)
- Francis the Caveman (primitive talk show host appeared in other sketches) (Season 5-6)
- Jack Campbell, Fat Cop (overweight policeman who uses crime scene investigations as an excuse to eat victims' food) (Season 4)
- Cheeseburger Doyle (voice only; a talking sandwich private detective who squirted mustard at suspects) (Season 6)
- Ralph Forrester (Aussie nature expert, spoof of Steve Irwin and Nigel Thornberry) (Season 6)
- Cruton (enemy Of USS Spaceship, Made Of Crutons) (Season 4)
- Bo Stallion (reporter of Channel 6 1/2 Sports) (Season 5)
- Helga (short tempered girl with a Dutch accent)(season 5-6)
Christy Knowings (seasons 4-6)
- Brenda Stone (self-absorbed, lazy news anchorwoman) (Season 5-6)
- Jessica (teenybopper co-host of "What-everrrrr!") (Season 4-6)
- Winter Wonders (host of "What Do You Do", spoof of Summer Sanders) (Season 4)
- Yoko (manipulative girlfriend of Disco, spoof of Yoko Ono) (Season 4)
- Hot Toe (enemy of Jimmy Bond, vixen with a big toe full of volcanic lava) (Season 4)
- Lt. Fondue (second communications officer of USS Spaceship under Captain Tantrum, spoof of Lt. Uhura on Star Trek) (Season 4)
- Jenny (assistant to Dr. Bynes) (Season 4)
- Gloria Bankhead (home decorator, spoof of Martha Stewart) (Season 6)
- Mrs. Kibbitz (Bernie's wife) (Season 4)
- Miss Klump (barely-competent Dullmont Junior High teacher, replaced Miss Fingerly) (Season 5-6)
- Penny Lane (reprising Bates and Reyes' role as Superdude's damsel in distress) (Season 4-5)
- Miss Williams (President of Dudco Enterprises, LaTanya's boss) (Season 6)
- Helga (Toby Bruan's Assistant,Strong Girl) (Season 4)
- LaTasha (Enemy Of Latanya And Lanisha) (Season 5)
- Lulu (Baby who discuses topics with brother Chester) (Season 6)
- Milly Fuco (Billy Fuco's Mom) (Season 6)
Leon Frierson (seasons 4-6)
- Leroy (cynical young kiddie-show host, enjoys abusing his puppet co-star, Fuzz) (seasons 4-6)
- Pillow Boy (sidekick to Boring Man, places pillows under sleeping criminals) (Season 6)
- Billy Fuco (loud boy who enjoys saying his own name) (Season 4-6)
- C.J. (short, cute leader of the Cloudy Knights, has biggest afro in the group) (Season 4)
- Repairboy-boy (Repairman's second opinion) (Season 4)
- Lester Oaks, Construction Worker, Jr. (son of Lester Oaks, Construction Worker) (Season 5)
- Mr. Big (enemy of Jimmy Bond, spoof of similar villain from James Bond) (Season 6)
- Boy In The Don't Do This At Home Or School Sketches (Boy Who Deminstrates What Not To do At School Or At Home) (Season 5)
Zack McLemore (season 4)
- Mr. Trevell (Wackjob Dullmont Music Teacher, Miss Fingerly has a crush on him)
Victor Cohn-Lopez (Season 4)
- Ricky Ricardo (spoof of the I Love Lucy character)
Nick Cannon (seasons 5-6)

- Sweaty Spice (Spice Boy who constantly perspires) (Season 5-6)
- LaTanya (self-centered female convenience store employee; Cannon later kept the character for his spinoff The Nick Cannon Show) (Season 5-6)
- Bingo (guy with giant afro) (Season 5-6)
- Bank Robber (A bank robber in a superhero sketch called boring man) (Season 6)
Mark Saul (seasons 5-6)

- Stuart (crazy young man who kidnaps people and tries to do their jobs) (Season 5-6)
- Arnie Fishback (nerdy boy) (Season 5)
- Andre (Gloria Bankhead's mute assistant, constantly annoys her) (Season 6)
- Hypno-Pants (nemesis of Boring Man, wears hypnotic trousers) (Season 6)
- Murray (stuttering child who loves balloons, Then pops them once he gets them.) (Season 6)
- Rhineheart the Dancing Monkey Boy (video clip used during "technical difficulties") (Season 5-6)
- Moby Braun (Toby Braun's little brother) (Season 6)
- Nigel Forrester (Aussie nature expert, spoof on Steve Irwin and Nigel Thornberry) (Season 6)
- Ricardo (conceited ladies' man) (Season 6)
- Dr. Maybe (enemy of Jimmy Bond, spoof of Dr. No) (season 5)
Gabriel Iglesias (season 6)

- Benji Martin (Ricky Martin's Brother)
- Bill Clinton (spoof of the then-president)
- Mr. Nice-Guy (enemy of Jimmy Bond, a villain who used politeness to conquer the world)
- Gomer
- Pizza Guy
- Chester (Baby who discusses topics with sister Lulu)
Second Run (seasons 7-10)
Chelsea Brummet (seasons 7-10)
- Polly Baboo (overly-nice "American Idiot" judge, spoof of Paula Abdul) (Seasons 8-9)
- Bridgett (boy-crazy host of televised slumber parties in her room) (Seasons 7-9)
- Sharon Osbourne (spoof of the television personality) (Seasons 7-9)
- Brittney (generic spoof of Britney Spears) (Seasons 7-8)
- Lil' Embryo's mama (mother/manager of an embyonic rapper) (Season 9)
- Abby Rhodes (ditzy teenage girl, named for the Beatles' album) (Season 10)
- Avril Lavigne (spoof of the singer)
- "Tea & Crumpets" lady (refined and uptight antithesis to the Sugar & Coffee hosts)
- Hick Sister 1 (Nashville-style singer, spoof of Wynonna Judd)
- Spella (witch from reality-show spoof "The Unreal World") (Seasons 8-9)
- Jessiquat Zortog (alien, owns Earth restaurant that serves soylent meat) (Season 10)
- Mega Butt (superhero with inflatable butt, member of "LAMOS" crimefighting team) (Season 10)

- Slimon Bowel (overly-cruel "American Idiot" judge, spoof of Simon Cowell) (Seasons 8-9)
- Rowdy Fan #1 (rabid fan of whatever's happening in the scene, friend of #2) (Seasons 7-9)
- Percy Flavin (dorky boy with whiny voice, sometimes hosts a cooking show with the Buford Rougeneck, possible spoof of {{W|Jerry Lewis}]) (Seasons 7-10)
- Ozzy Osbourne (spoof of the singer) (Seasons 7-9)
- Clem Rougeneck (uneducated head of the Rougeneck clan, and unaware that his mother is dead) (Seasons 8-10)
- Randy Quench (insane volunteer fireman who overreacts to anything involving heat) (Seasons 8-10)
- Brad Dashman (philandering conceited football player, boyfriend of Heather) (Seasons 9-10)
- Carson Daly (spoof of the Total Request Live host) (Seasons 7-8)
- Vlad (vampire from "The Unreal World") (Seasons 8-9)
- Papa Zortog (alien, owns Earth restaurant that serves soylent meat) (Season 10)
- Dr. Fist (evil villain with giant fist, fights "LAMOS") (Season 10)

- Claudia (dark, gothic friend of Bridgett, has magical powers, also reads morbid poetry to small children) (Seasons 7-10)
- Herheiney (friend of Harry Bladder, spoof of Hermione Granger) (Seasons 7-8)
- Mama Rougeneck (Co-head of the Rougeneck clan) (Seasons 7-10)
- Kelly Osbourne (spoof of Ozzy and Sharon's daughter) (Seasons 7-9)
- Heather Darling (philandering conceited cheerleader, girlfriend to Brad) (Seasons 9-10)
- Spirit (ghost of a cheerleader from "The Unreal World") (Seasons 8-9)
- Vocabulary Girl (Lisa teaches the audience new words, while a ventriloquist dummy uses the words to mock her) (Seasons 7-9)
- Venice Hyatt (airhead socialite, spoof of Paris Hilton) (Seasons 9-10)
- Kaffy (over-caffeinated co-host of "Sugar & Coffee") (Seasons 7-10)
- Hick Sister 2 (Nashville-style singer, spoof of Dolly Parton)
- Lactose Intolerance-Definer (reprised Katrina & Amanda's role when Kenan guest-starred in season 7)
- Marlee (co-hosts "Trashin' Fashion", loosely references Joan Rivers) (Seasons 8-9)
- Elaine Fist (wife of Dr. Fist) (Season 10)
- Supermodel (a villain who can turn supermodels into mannequins, appeared in an un-aired "LAMOS" sketch) (Season 10)

- Bryan Peafest (essentially useless host of "American Idiot", spoof of Ryan Seacrest) (Seasons 7-9)
- Harry Bladder (spoof of Harry Potter) (Seasons 7-8)
- Jack Osbourne (spoof of Ozzy and Sharon's son) (Seasons 7-9)
- Ernie (young intern operator of the "Tilt-A-Hurl" ride) (Seasons 7-9)
- Vince Laffoon (host of "Sneaky Camera") (Season 9)
- Max (enthusiastic children's show host, outfit suggests spoof of Steve Burns)
- Elliot (Bridgett's standard-issue annoying little brother) (Seasons 7-9)
- Gabe (accountant from "The Unreal World" who does not know he is a werewolf and fears all of his co-inhabitants) (Seasons 7-9)
- Dr. Laser (superhero with Class II laser pointer fingers, member of "LAMOS") (Season 10)
- Buzz (over-sugared co-host of "Sugar & Coffee") (Seasons 7-10)
- Rougeneck Introducer (well-to-do boy in classy surroundings who introduces each Rougeneck skit) (Seasons 7-10)
- Claude Grimes (An Australian cooking-show host) (Seasons 9-10)

- Bucketman (powerful radioactive superhero with a bucket stuck over his head) (Seasons 7-8)
- Rowdy Fan #2 (rabid fan of whatever happens in the sketch, friend of #1) (Seasons 7-9)
- Buford Rougeneck (unintelligent son of the Rougeneck family, also Percy's cooking show host) (Seasons 7-9)
- Murray (clumsy roofer)
- Frank (spoof of Frankenstein's monster from "The Unreal World") (Seasons 8-9)
- Cupid (mascot of "2-Gether 4-ever" starring Brad & Heather) (Season 9)
- Saco (brash parody of Draco Malfoy)
- Soupdude (superhero who makes delicious soup dishes to stop criminals) (Season 7)
- Himself (Shane fights a variety of things, always losing, also in "Advice from the Old Lady in Shane's Mouth") (Seasos 7-9)

- Mandy Snackson ("American Idiot" judge who constantly says "You did your thing, dog", spoof of Randy Jackson) (Seasons 8-9)
- Stacy Chit (host of "Chit Chat", where she frequently become bored with her guests) (Seasons 7-9)
- Gail (naive & sunny participant in Bridgett's slumber parties) (Seasons 7-9)
- Ms Fishtail (driving instructor who intentionally distracts her students while they drive)
- Pharah (sassy Egyptian mummy from "The Unreal World") (Seasons 8-9)
- Zit-Connector (Draws simple pictures using back-pimples) (Seasons 7-8)

- Lil' Fetus (rapper who has yet to be born, spoof of Bow Wow, Lil' Romeo & others) (Seasons 7-8)
- Zigfried (foreign-born cabbie who drives terribly and frequently calls people kumquats)
- Mr. Flopples (unenthusiastic children's show character, suggested spoof of the title character of Blue's Clues)
- ReRon (precocious best friend of Harry Bladder, spoof of Ron Weasley) (Seasons 7-8)

- Thelma Stump (elderly All That security guard with a love of bacon) (Seasons 8-9)
- Betty Jo Rougeneck (middle child of the Rougeneck clan) (Seasons 8-9)
- Pickles (sadistic elf who torments Mr. Flopples) (Season 8)
- Zoe (barely animate zombie on "The Unreal World") (Seasons 8-9)
- Carlee (co-hosts "Trashin' Fashion", loosely references Melissa Rivers) (Seasons 8-9)

- Lil' Embryo (rapper even younger than Lil' Fetus) (Season 9)
- Head (disembodied and disgruntled head of a New Yorker on "The Unreal World") (Season 9)
- Poncy Flavin (Percy's sister) (Seasons 9-10)
- Cindy Lou Rougeneck (the baby of the Rougeneck family) (Seasons 9-10)
- Sunshine Sally (a talking doll that drives children insane at their parents' request) (Seasons 9-10)
- Bernice (Bernie Kibbitz's great granddaughter, appeared in the 10th Anniversary show)
- Zsa Zsa Zortog (daughter of Mama & Papa Zortog) (Season 10)
- Squat (Claude's dirty assistant) (Seasons 9-10)
- Roxy McDoogle (escaped juvenile convict) (Season 10)
- Jen Rollands (Channel 6 1/2 News reporter) (Season 10)

- Ed (reprising Kel Mitchell's role) (Seasons 9-10)
- The Sprinkler (half-man/half-sprinkler, member of "LAMOS") (Season 10)
- Jim Tasty (edible grade-school student) (Seasons 9-10)
- Rex Firestone (host of "Everything") (Season 10)
- Rodney Quench (Nephew of Randy Quench: Volunteer Fireman) (Seasons 9-10)

- Kareena Jones (an old, dangerously negligent bus driver, name is a play on the word careen)
- Kyra Stanks (a geeky spoof of Tyra Banks)

- Gwok Zortog (son of Mama & Papa Zortog)
- The Barber (superhero who styles hair, member of "LAMOS")
- Cupid 2 (new mascot of "2gether 4ever")
- Jeff Bester (safety tester who deems products unsafe by using them abusively)
- Harry Snuffer (old boyfriend of Kareena Jones)
- Ben Rollands (Channel 6 1/2 News reporter)
Lil' JJ (season 10)
- Vital Information dude (reprising sketch once done by Denberg and Tamberelli)
Adults
Dan Schneider (seasons 1-10)
- Mr. Bailey (manager of Good Burger after season 1)
- "Ask Ashley" Announcer (weird voice that leads into & out of "Ask Ashley" skits)
- Old Lady in Shane's Mouth (see name)
- "Know Your Stars" Announcer (reprising Brian Peck's role) (Seasons 9-10)
Ms. Bubbell
Soup (seasons 1-6)
- Announcer
Kevin Kopelow (seasons 1-6)
- Kevin the stage manager (tells the cast when they have 5 minutes to air, then is abused by the cast)
Tim Goodwin (seasons 1-3)
- Manager of Good Burger (Unnamed manager of Good Burger during season 1. Later replaced by Dan Schneider)
- Usually plays a dad.
Brian Peck (seasons 7-10)
- Pickle Boy (a mute man who shares his love of pickles with all)
- "Know Your Stars" Announcer (an unseen voice that mocks cast members and guest stars) (Seasons 7-8)
Jeremy Rowley (seasons 7-8)
- Professor Chafe (mean teacher of Harry Bladder, spoof of Severus Snape)
- "Tilt-A-Hurl" Operator (very messy man, due to his job)
- "Rate the Pain" Victim (man who receives an injury, then rates it from 1-10)
Britney Spears (various episodes throughout the series)
- Herself
Unknown
- Fat Cheerleader (woman who just screams, season 9)
- Mee-Ma Rougeneck (deceased mother of Papa Rougeneck, seasons 9-10)
- Lil' Fetus's mother (fetal rapper's mom/manager, seasons 7-8)
- "Connect the Zits" canvas (man with back acne who is drawn upon by Giovannie, seasons 7-8)
- Old Man (a man who is old, member of "LAMOS", season 10)
- Hillbilly Jug Band (A hillbilly band with midgets, season 9)
- Maude (Kyle's elderly girlfriend, season 10)
Prop Characters
- The Big Ear of Corn - see name, seasons 1-6,
- Fuzz (Kevin Carlson) - an annoying puppet, seasons 4-6
- Dead Spice - a guitar-playing skeleton, seasons 5-6
- Action League Now! - action figures, sometime during season 1
- Oswald (Dan Schneider) - an obnoxious ventriloquist dummy, season 7-9
- Mr. Artichoke Head - inanimate doll owned by Kareena Jones, season 10