The following is a list of programs broadcast by the American nighttime block Nick at Nite.
Television shows
Programs are ordered by the period during which they aired on Nick at Nite, as opposed to the period in which they originally aired.
Formerly broadcast
1980s debuts
| Dennis the Menace | 1985-1994 |
| The Donna Reed Show | 1985-1995 |
| My Three Sons | 1985-1991, 1995, 2000 |
| National Geographic Explorer | 1985-1986 |
| Nick at Nite Movie | 1985-1989 |
| Route 66 | 1985-1987, 1995 |
| Turkey Television | 1985-1987 |
| Mister Ed | 1986-1993, 1995, 1997 |
| I Spy | 1986-1988, 1995, 1998 |
| The Smothers Brothers Show | 1986-1989, 1995 |
| The Ann Sothern Show | 1987-1990, 1995 |
| The Bad News Bears | 1987-1988 |
| Car 54, Where Are You? | 1987-1990, 1995 |
| Mad Movies with the L.A. Connection | 1987-1989 |
| Make Room for Daddy | 1988-1991, 1995 |
| The Monkees | 1987-1988, 1996-1998 |
| Rowan & Martin's Laugh-In | 1987-1990, 1995, 1997 |
| Susie | 1987-1990, 1995 |
| Lancelot Link, Secret Chimp | 1988-1989, 1995 |
| The Patty Duke Show | 1988-1992, 1995 |
| Saturday Night Live | 1988-1991, 1997 |
| SCTV | 1988-1990, 1995 |
| Looney Tunes | 1989-1993 |
| Bewitched | 1989-1991, 1994-2000 |
| Green Acres | 1989-1992, 1996-1998 |
| Lassie | 1989-1996 |
| Hazel | 1989-1996 |
| On the Television | 1989-1991 |
1990s debuts
2000s debuts
| The Beverly Hillbillies | 2000-2002 |
| Gilligan's Island | 2000-2002 |
| The Andy Griffith Show | 2000-2002 |
| Head of the Class | 2003 |
| Perfect Strangers | 2003 |
| Rosie | 2000—2002 |
| Gimme a Break! | 2000-2003 |
| The Facts of Life | 2000-2001, 2003 |
| Three's Company | 2000-2006 |
| Roc | 2001 |
| Diff'rent Strokes | 2001-2002 |
| Silver Spoons | 2001 |
| ALF | 2001 |
| 227 | 2001 |
| Family Ties | 2001-2003, 2005 |
| Cheers | 2001-2004 |
| Kids Say the Darndest Things | 2001-2003, 2005 |
| The Cosby Show | 2002-2010 |
| Charles in Charge | 2002-2003 |
| Coach | 2002-2003 |
| Wings | 2003-2005 |
| Roseanne | 2003-2009 |
| Full House | October 6, 2003 - September 28, 2021 |
| Sabrina The Teenage Witch | 2003-2005 |
| The Fresh Prince of Bel-Air | 2004-2009, 2014-2018 |
| Who's The Boss? | 2004-2006 |
| Family Face Off: Hollywood | 2004-2005 |
| Fatherhood | 2004-2005 |
| Murphy Brown | 2005-2007 |
| Hi-Jinks | 2005-2008 |
| The Jeff Foxworthy Show | 2005-2006 |
| The Search For The Funniest Mom In America | 2005-2007 |
| At the Poocharelli's | 2006 |
| Designing Women | 2006-2008 |
| A Different World | 2006-2008 |
| Mad About You | 2006-2008 |
| NewsRadio | 2006 |
| America's Funniest Home Videos (1989-1994 episodes) | 2007 |
| Bet the House | 2007-2008 |
| Growing Pains | 2007-2008 |
| Home Improvement | 2007-2012 |
| Nick at Nite Tuesday Movie of the Week | 2007 |
| The Landry Sisters | 2007-2012 |
| George Lopez | 2007-2020 |
| Family Matters | 2008-2012 |
| The Nanny | 2009-2013 |
| Malcolm in the Middle | 2009-2010 |
| Glenn Martin, DDS | 2009-2012 |
| Everybody Hates Chris | 2009-2012 |
2010s debuts
| Hot in Cleveland | 2010-2016 |
| My Wife and Kids | 2010-2014 |
| That '70s Show | 2011-2014 |
| Happily Divorced | 2011 |
| Married... with Children | 2011 |
| Yes, Dear | 2012-2014 |
| See Dad Run | 2012-2014 |
| Wendell & Vinnie | 2013 |
| Instant Mom | 2013-2015 |
| The New Adventures of Old Christine | 2013-2014 |
| How I Met Your Mother | 2014-2015 |
| Everybody Loves Raymond | 2015 |
| Younger | 2015-2016 |
| The Jim Gaffigan Show | 2015-2016 |
| Impastor | 2015-2016 |
| Teachers | 2015-2016 |
| Lopez | 2015-2016 |
| Nashville | 2016-2017 |
| The Goldbergs | 2017-2018 |
| Two and a Half Men | 2017-2018 |
| The Office | 2019 |
| The King of Queens | 2019 |
| Awkwafina Is Nora from Queens | 2020 |
| Young Sheldon | 2020-2024 |
| Seinfeld | 2022 |
Current programming
| Friends | September 5, 2011-present |
| Mom | July 2, 2018-present |
| Mike & Molly | October 5, 2021-present |
Television specials
On occasion, the programs Rugrats and SpongeBob SquarePants aired as marathons during Nick at Nite special events in the 1990s and 2000s. This has also occurred during crossovers with Nickelodeon special programming where the Nickelodeon programming bleeds into the regular Nick at Nite timeslot. As of March 2024, SpongeBob regularly airs on Nick at Nite at 6:30 AM every weekday and weekend mornings from 6:00-7:00 AM. From October 5-November 12, 2021, The Smurfs also regularly aired at 6:30 AM on weekdays.
Notes
1 Indicates program that had also been broadcast on Nickelodeon.
2 Indicates program that had also been broadcast on NickMom.
3 Indicates program that is/had also been on TV Land.
4 Indicates program that aired as part of Nick at Nite's 20 Years.