Tress MacNeille (born June 20, 1951) is an American voice actress best known for providing various voices on the animated series The Simpsons, Futurama, Tiny Toon Adventures, Animaniacs, Disney's House of Mouse, Courage the Cowardly Dog, Chip 'n Dale Rescue Rangers, and Dave the Barbarian.
Her most notable roles on Nickelodeon come as Charlotte Pickles on Rugrats and All Grown Up!, a role reprised for The Rugrats Movie, Rugrats in Paris: The Movie, and Rugrats Go Wild, and is also known as Gertie, Arnold's grandmother, and Mayor Dixie on Hey Arnold!, roles reprised for Hey Arnold!: The Movie, and Hoodsey Bishop on As Told by Ginger.
She also voiced Ms. Slovak, Arnold's first teacher. In less major roles, she voiced a fly in an episode of ChalkZone, Hama and Avatar Yanchen in separate episodes of Avatar: The Last Airbender, Sassafrass in an episode of Catscratch, and minor characters in Random! Cartoons and Back at the Barnyard.